Phytochemical Characterization and Antiplatelet Activity of Mexican Red Wines and Their By-products

  • Ó.A. Muñoz-Bernal Departamento de Ciencias Químico-Biológicas
  • L.A. de la Rosa Departamento de Ciencias Químico-Biológicas
  • J. Rodrigo-García Departamento de Ciencias de la Salud, Ciudad Juárez, Chihuahua, México
  • N.R. Martínez-Ruiz Departamento de Ciencias Químico-Biológicas
  • S. Sáyago-Ayerdi Tecnológico Nacional de México/Instituto Tecnológico de Tepic
  • L. Rodriguez Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences
  • E. Fuentes Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences
  • E. Alvarez-Parrilla Universidad Autónoma de Ciudad Juárez http://orcid.org/0000-0002-6162-8139

Abstract

Red wines and their grape pomaces are important sources of phenolic compounds. Inhibition of platelet
aggregation is one of the mechanisms proposed for cardioprotective effect of phenolic compounds from
wine and grape pomace; however, phenolic content is affected by region, variety and winemaking process.
In the present study, antiplatelet effect of red wines and grape pomaces was related to its phenolic content
(determined by spectrophotometric techniques) and profile (determined using HPLC-MS/MS). in vitro
Anti-platelet aggregation was determined using human platelets. Results showed that Zinfandel wine and
Cabernet Sauvignon grape pomace presented the highest phenolic content. Phenolic profiles presented
differences in the presence of flavonoids and oligomeric tannins. Results from platelet aggregation
showed that Merlot and Petit Verdot wines and Petit Verdot grape pomace sample presented the highest
antiaggregant effect. These results indicate that antiplatelet effect could be related to phenolic profile than
phenolic content in wines and grape pomaces. Cardioprotective effect of red wines and grape pomace
could be related to specific compounds such as monomeric and polymeric flavan-3-ols.

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Author Biographies

L.A. de la Rosa, Departamento de Ciencias Químico-Biológicas

Departamento de Ciencias Químico-Biológicas

J. Rodrigo-García, Departamento de Ciencias de la Salud, Ciudad Juárez, Chihuahua, México

Departamento de Ciencias de la Salud, Ciudad Juárez, Chihuahua, México

N.R. Martínez-Ruiz, Departamento de Ciencias Químico-Biológicas

Departamento de Ciencias Químico-Biológicas

S. Sáyago-Ayerdi, Tecnológico Nacional de México/Instituto Tecnológico de Tepic

Tecnológico Nacional de México/Instituto Tecnológico de Tepic, Col. Lagos del Country, Tepic, Nayarit

L. Rodriguez, Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences

Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences

E. Fuentes, Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences

Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences

E. Alvarez-Parrilla, Universidad Autónoma de Ciudad Juárez

Universidad Autónoma de Ciudad Juárez, Departamento de Ciencias Químico-Biológicas

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Published
2021-04-16
Section
Articles