Ethnic differences in risk factor profiles in subjects with coronary disease attending a state hospital in KwaZulu-Natal
Abstract
Objectives: This study compares the profile of coronary artery disease (CAD) across different ethnic groups at a tertiary referral hospital in KwaZulu-Natal.
Method: We reviewed the clinical records of 1 104 subjects who underwent coronary angiography at Grey’s Hospital for suspected CAD over a 5-year period (2012 - 2016). Uni- and multivariable analysis was used to identify associations of risk factors with CAD.
Results: Coronary artery disease was present in 886 subjects, of whom 69.9% were male. The majority were of Indian ethnicity (60.8%). The mean age of Africans was younger (54.9 ± 10.8 years) compared to Indians (58.0 ± 11.0 years), Coloureds (58.6 ± 12.3 years) and Whites (60.0 ± 10.5 years) (p=0.001). The prevalence of premature CAD (PCAD) (<55 years in males and <65 years in females) was 46% of males and 66,7% in females. Most African females (84,6%, p=0.01) and white females (75,6%, p=0.01) presented with PCAD. ST-elevation myocardial infarction was the most frequent presentation among African subjects (n=99, 66.0%), followed by Whites (n=76, 45.2%) and Indians (n=240, 44.5%), and least common among Coloureds (n=11, 37.9%) (p<0.001). The most prevalent risk factors were dyslipidaemia (95.1%), hypertension (70.3%), smoking (67.4%) and diabetes (57.2%). The prevalence of smoking was lowest in the African group (51.3%) compared to about 66% in the other groups (p<0.001) (Table I). About 80% of Indians and Whites had clustering of 3 or more risk factors compared to 39.3% of Africans (p<0.001). A family history of CAD lowest among African (n=13, 8.7%) and Coloured subjects (n=11,37.9%) (p<0.001) and a history of previous MI was obtained in 5.3% of African subjects compared to >23% in each of the other ethnic groups (p<0.001). Single vessel disease was commoner among Africans (48.7%), while Indians had more triple vessel disease (47.7%), (p<0.001). Univariate analysis identified risk factors and ethnicity (Indians, p=0.02) and Whites, p=0.02) as being associated with CAD, but on multivariable analysis ethnicity fell away. Age (46 - 65 years: OR: 2.2 [1.5 - 3.3], age >65 years: OR: 4.8 [2.8 - 8.2], male gender (OR: 2.7 [1.9 - 3.9]), history of smoking (OR: 2.0 [1.4 - 3.1] (all p<0.001) as well as diabetes (OR: 1.7 [1.2 - 2.4], p=0.005) and atherogenic dyslipidaemia (OR: 1.7 [1.2 - 2.4], p=0.004) were independent cardiovascular risk factors associated with the presence of CAD.
Conclusion: Major risk factors were associated with CAD at a young age across all race groups. Although Africans had a lower risk factor burden, the low prevalence of a family history of MI and near absence of a previous history of MI indicate that recent environmental and / or lifestyle changes that have contributed to the emergence of CAD, often premature, in this group.
Downloads
Copyright (c) 2025 SA Heart Journal

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
This journal is an open access journal, and the authors and journal should be properly acknowledged, when works are cited.
Authors may use the publishers version for teaching purposes, in books, theses, dissertations, conferences and conference papers.Â
A copy of the authors’ publishers version may also be hosted on the following websites:
- Non-commercial personal homepage or blog.
- Institutional webpage.
- Authors Institutional Repository.Â
The following notice should accompany such a posting on the website: “This is an electronic version of an article published in SAHJ, Volume XXX, number XXX, pages XXX–XXX”, DOI. Authors should also supply a hyperlink to the original paper or indicate where the original paper (http://www.journals.ac.za/index.php/SAHJ) may be found.Â
Authors publishers version, affiliated with the Stellenbosch University will be automatically deposited in the University’s’ Institutional Repository SUNScholar.
Articles as a whole, may not be re-published with another journal.
Copyright Holder: SA Heart Journal
The following license applies:
Attribution CC BY-NC-ND 4.0