Relationship between soluble F11 receptor and ischemic heart disease in hemodialysis patients

Seham Bakry; Ahmed Bahgat El-demery

doi:10.21804/14-1-767

Seham Bakry Departments of Internal Medicine, Cairo University and Biochemistry, Faculty of Medicine 6th October University, Cairo, Egypt
Ahmed Bahgat El-demery Departments of Internal Medicine, Cairo University and Biochemistry, Faculty of Medicine 6th October University, Cairo, Egypt

Abstract

Background: Cardiovascular disease is a major cause ofmorbidity and mortality in hemodialysis patients, there isincreasing evidence that platelets are major contributorsto atherosclerosis, which is mediated through F11receptors.

Methods: Our study included 40 hemodialysis patientsdivided into two groups:Group 1: included 20 hemodialysis patients withischemic heart disease (IHD), Group 2: included 20hemodialysis patients without ischemic heart disease,they were compared with 20 age and sex matchedcontrols, soluble F11 receptor (sF11R) and highsensitivity C-reactive protein (hs-CRP) were measuredby enzyme-linked immunosorbent assay (ELISA).

Results: sF11R was significantly higher in hemodialysispatients than controls; it showed significant differencebetween group 1, group 2 patients and controls. sF11Rshowed significant positive correlation with hs-CRP.

Conclusion: sF11R can be considered a marker of IHDin hemodialysis patients.