IL-10 Gene polymorphism and graft outcome in live-donor kidney transplantation

Rashad Hassan Rashad; Khaled Mohamed Mahmoud; Amgad El-Baz El-Agroudy; Ahmed Farouk Hamdy; Amani Mostafa Ismail; Nagy Abd-El Hady Sayed; Mohamed Abd El-Kader Sobh

doi:10.21804/19-1-1485

Rashad Hassan Rashad Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura
Khaled Mohamed Mahmoud Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura
Amgad El-Baz El-Agroudy Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura
Ahmed Farouk Hamdy Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura
Amani Mostafa Ismail Department of Immunology, Urology and Nephrology Center, Mansoura University, Mansoura
Nagy Abd-El Hady Sayed Internal Medicine Department, Mansoura University, Mansoura
Mohamed Abd El-Kader Sobh Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura

Abstract

Background: The description of polymorphisms in many of the key immunoregulatory molecules involved in the rejection process has offered a possible explanation for the individual variation in susceptibility to rejection and differences in allograft survival independent of the many known contributory factors. The aim of this work is to study the impact of IL-10 cytokine gene polymorphism on renal transplant clinical course and outcome.

Methods: This work studied 50 transplant recipients maintained on sirolimus based immunosuppression for IL-10 cytokine gene polymorphisms. After transplantation patients were divided into two groups. Group (A) patients (12 patients) received sirolimus, tacrolimus and steroid, while Group (B) patients (38 patients) received sirolimus, mycophenolate mofetil and steroid. Results were correlated with acute and chronic rejection episodes as well as graft and patient outcome.

Results: In our study, we found no impact of IL-10 on incidence and degree of acute rejection episodes, incidence of chronic allograft nephropathy, pathological changes in protocol biopsies, graft function and graft and patient survivals.

Conclusion: From this work, we can conclude that the potential impact of IL-10 cytokine gene polymorphisms on renal transplant clinical course and outcome have shown no influence, and probably other genes rather than IL-10 could be involved as key molecules for graft function.