Safety and efficacy of percutaneous closure of perimembranous ventricular septal defects in children: Review of the results at Inkosi Albert Luthuli Central Hospital

Marelize Bosman, Ebrahim Hoosen, Joseph Degiovanni


Background/Hypothesis: Ventricular septal defect (VSD) is the most common congenital cardiac lesion. Surgical closure is the gold standard, but in an isolated perimembranous ventricular septal defect (PMVSD), percutaneous closure is an attractive alternative, particularly in a limited resource setting. Our experience suggests that percutaneous closure of a perimembranous VSD, in the appropriately selected patient, is safe and effective.

Materials and methods: We performed a retrospective chart review of all children that underwent percutaneous closure of a PMVSD at Inkosi Albert Luthuli Central Hospital, from October 2010 until December 2016. Patients that had percutaneous closure of any VSD other than PMVSD, including residual VSD postsurgical closure, were excluded.

Results: Fourty two patients were included in our retrospective analysis, 27 females and 15 males, with a mean age of 6 years 6 months (Range: 2 years 9 months – 15 years 9 months). Mean follow-up was 2 years 3 months. Successful device delivery was achieved in 97.6%. A total of 30 patients (71.4%) had complete closure of their defect. Eleven (26.2%) patients had a residual but haemodynamically insignificant defect. Two patients had mild aortic regurgitation post procedure. Significant early complications included 1 patient with moderate tricuspid regurgitation and 2 patients with device embolisation. In one of these patients, the embolised device was retrieved and replaced with a larger device. In the second patient, surgical retrieval and closure was required. No cases of heart block were recorded.

Conclusions: In our experience, percutaneous closure of a perimembranous ventricular septal defect in a child appears to be safe and effective.


Ventricular septal defect; perimembraneous ventricular septal defect; percutaneous closure

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