Biological and Health-promoting Activity of Vinification Byproducts Produced in Spanish Vineyards

  • J. Anter Department of Genetics, University of Córdoba, Campus Rabanales, 14071 Córdoba, Spain
  • S. Demyda-Peyras Department of Genetics, University of Córdoba, Campus Rabanales, 14071 Córdoba, Spain
  • M. del Pilar Delgado de la Torre Department of Analytical Chemistry, University of Córdoba, Campus Rabanales, 14071 Cordoba, Spain
  • J. Campos-Sanchez Department of Genetics, University of Córdoba, Campus Rabanales, 14071 Córdoba, Spain
  • M.D. Luque de Castro Department of Analytical Chemistry, University of Córdoba, Campus Rabanales, 14071 Cordoba, Spain
  • A. Muñoz- Serrano Department of Genetics, University of Córdoba, Campus Rabanales, 14071 Córdoba, Spain
  • Á. Alonso-Moraga Department of Genetics, University of Córdoba, Campus Rabanales, 14071 Córdoba, Spain
DOI: https://doi.org/10.21548/36-1-945

Abstract

Several by-products are produced in the Spanish agricultural system. Among them, fresh and vinified
grape skins represent an abundant source of phenols with a potential nutraceutical value. Fresh grape skin
extracts (FGSE) and vinification of grape skin extracts (VGSE) obtained by a microwave-assisted method
have been chemically and biologically characterised. Their role in the maintenance of genetic stability
was stated by in vivo genotoxic and antigenotoxic evaluations (Drosophilla melanogaster wing spot test), as
well as by their potential chemopreventive effect (in an HL60 in vitro model). Total phenolic, anthocyanin
and resveratrol contents were chemically characterised in the two extracts, showing some qualitative
differences. Both extracts and resveratrol were not mutagenic in the Drosophila somatic mutation and
recombination tests, and exerted antigenotoxic activities against hydrogen peroxide. They also showed
cytotoxic activity to HL60 leukaemia cells, with an IC50 of 4.5μL/mL, 4.6μL/mL and 98μM respectively and
induced apoptotic internucleosomic fragmentation in the HL60 cell line.

Downloads

Download data is not yet available.
Published
2016-09-12
Issue
Vol. 36 No. 1 (2015)
Section
Articles

A copyright form will be e-mailed to the corresponding author when the manuscript has been accepted for publication.

 

In principle, the Author agrees to the following when he/she signes the copyright agreement:

I hereby assign to the SOUTH AFRICAN SOCIETY FOR ENOLOGY AND VITICULTURE (SASEV) the copyright of the text, tables, figures, supplementary material, illustrations and other information (the Material) submitted with the manuscript to be published in SOUTH AFRICAN JOURNAL OF ENOLOGY AND VITICULTURE (SAJEV) (the "Article"). The copyright becomes effective from the date the Article has been accepted for publication in SAJEV.

 

This is an open access journal, and the authors and journal should be properly acknowledged, when works are cited.

Author's may use the publishers version for teaching purposes, in books, theses, dissertations, conferences and conference papers.

A copy of the authors' publishers version may also be hosted on the following websites:

  • Non-commercial personal webpage or blog.
  • Institutional webpage.
  • Authors Institutional Repository.

The following notice should accompany such a posting on the website: This is an electronic version of an article published in SAJEV, Volume XXX, number XXX, pages XXX - XXX, DOI.   Authors should also supply a hyperlink to the original paper or indicate where the original paper (www.journals.ac.za/index.php/sajev/) may be found.

Authors publishers version, affiliated with the Stellenbosch University will be automatically deposited in the University's Institutional Repository SUNScholar.

Articles as a whole, may not be re-published with another journal.

The following license applies:

Attribution CC BY-NC-ND 4.0